Medworm Celiac Disease News

Canadian researchers are testing a new drug for patients who suffer from a chronic digestive disorder called celiac disease, which appears to be afflicting a growing number of people. (Source: CTV Health)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Conclusions: Expression and synthesis of fls485 are found in surface lining epithelia of normal human intestinal mucosa and deriving epithelial cell lines. An interdependence of enterocyte differentiation along the crypt-villus axis and fls485 chaperone activity might be possible. (Source: BMC Gastroenterology)

When celiac disease is diagnosed in adulthood, mucosal damage might never completely resolve, even on a gluten-free diet, according to a February 9th online report in The American Journal of Gastroenterology. Reuters Health Information (Source: Medscape Gastroenterology Headlines)

Researchers have developed a new instrument specifically for measuring quality of life in patients with celiac disease. (Source: MedWire News - Gastroenterology)

(Source: Gut)

Conclusions Endocytic segregation of gliadin peptide AA 31–49 seems to be a constitutive process. It explains why this peptide cannot stimulate gluten-sensitive T cells. Presentation of gliadin peptides by HLA-DR proteins via late endosomes within enterocytes might induce a tolerogenic effect and constitutes a potentially promising therapeutic approach for induction of tolerance towards gliadin. (Source: Gut)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Conclusion p31–43 accumulation in lysosomes leads to epithelial activation via the ROS–TG2 axis. TG2 works as a rheostat of ubiquitination and proteasome degradation and drives inflammation via PPAR downregulation. (Source: Gut)

Recent research findings indicate a possible connection between virus infections, the immune system and the onset of gluten intolerance, also known as celiac disease. (Source: ScienceDaily Headlines)

(Academy of Finland) Recent research findings indicate a possible connection between virus infections, the immune system and the onset of gluten intolerance, also known as celiac disease. (Source: EurekAlert! - Medicine and Health)

Introducing gluten to a baby's diet during a period of infection does not increase the risk of celiac disease, Swedish researchers report in the March issue of Pediatrics. Reuters Health Information (Source: Medscape Medical News Headlines)

For every recognized case of celiac disease, 8 more remain undiagnosed. The reason for this disparity is contingent on the varying presentations of the disease. (Source: Consultant Live)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

Endoscopy 2010; 42: 197-202DOI: 10.1055/s-0029-1243937 Improved endoscopic screening with targeted biopsies might enhance diagnostic yield in celiac disease. Confocal endomicroscopy (CEM) allows high-resolution in vivo histological analysis. We compared the endomicroscopic findings during ongoing endoscopy with the histological findings graded according to the Marsh classification.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Endoscopy)

Endoscopy 2010; 42: 218-219DOI: 10.1055/s-0029-1243903© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: Endoscopy)

New research has identified four aspects of immune system disturbance which lead to the development of coeliac disease. Nearly 40 different inherited risk factors which predispose to the disease have now been identified... (Source: Nutrition/Agriculture News From Medical News Today)

New research has identified four aspects of immune system disturbance which lead to the development of coeliac disease. Nearly 40 different inherited risk factors which predispose to the disease have now been identified. These latest findings could speed the way towards improved diagnostics and treatments for the autoimmune complaint that affects 1 in 100 of the population, and lead to insights into related conditions such as type 1 diabetes... (Source: Health News from Medical News Today)

In a genomewide study, more than half the variants associated with celiac disease correlated with altered activity of nearby genes. Medscape Medical News (Source: Medscape Today Headlines)

MedWorm Sponsor Message: Find a vast selection of gluten free food and GF cookbooks at the Sensible Celiac.

CONCLUSION: A number of preclinical and low-grade symptomatic patients with CD may be identified by their responses to a mailed questionnaire. (Source: PEDIATRICS)

CONCLUSIONS: Children who had CD and attended a week-long gluten-free camp demonstrated improvement in well-being, self-perception, and emotional outlook. The positive effects of camp were more apparent among campers who had been on a GFD for <4 years compared with those who had been on a GFD for ≥4 years, suggesting an adaptation to CD with time. A gluten-free camp that provides an environment of unrestricted foods can at least temporarily alleviate stress and anxiety around food and social interactions. Durability of these observations on return to daily life requires additional study. (Source: PEDIATRICS)

CONCLUSION: These results indicate that parent-reported infection at the time of gluten introduction is not a major risk factor for CD. (Source: PEDIATRICS)

A UK-led international study has identified four types of genetic disturbance in the immune system that lead to celiac disease, bringing to 40 the total number of known inherited factors that increase a person's risk of developing the disease... (Source: GastroIntestinal News From Medical News Today)